Haggling with HAGMA: A Common Medication with an Uncommon Differential Renal Fellow Network Acetaminophen toxicity EMCrit Project Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Glutathione Depletion LivOn Labs